In a modern economy SMEs have to function beside the large enterprises in an efficient way. Both large enterprises and small enterprises have a role and weighted well defined on the market, in the light of the priorities on which the economy and social structure requires. In the period of crisis, however, the priorities of operation of the economy changes being needed major adjustments, the ratio between large enterprises and small. One way to achieve this modernization would be stimulate the market free of the capital particularly that aimed at SMEs. This paper will present, most important characteristics which would be the most important of the report between large and small enterprises, how should operate and which would be factors influencing development of the small and medium-sized in the period of the crisis. Establishing an optimal ratio between large companies and SMEs by stimulating the development of the latter would be one way to mitigate the dramatic effects of the crisis period.