The article intends to present the achievements of a research Romanian project “Knowledge management architecture in environmental, social and economic areas, designed to support the sustainable regional development strategy”. The main goal of the project is to improve the regional knowledge management, using a virtual framework for the design of the regional development strategy. The innovation introduced by this approach consists in the integration of the regional actors' views, in order to develop a realistic regional development strategy, on a democratic and scientific base. The challenge of this vision is to create a virtual environment for the regional knowledge management and consensus building related to the regional strategy development. The scientific base for the design of the regional development strategy is represented by an improved set of socio- economic indicators and benchmarking tools.